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Levitra

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What is Levitra?

Levitra (Vardenafil is a prescription drug used for the treatment of erectile dysfunction (ED), a condition that is also addressed by drugs such as sildenafil (Viagra) and tadalafil (Cialis). The efficacy of vardenafil, sildenafil, and tadalafil all depend on their ability to inhibit the enzyme phosphodiesterase-5 (PDE-5), which plays a key role in regulating blood flow to and from the penis.

How is Levitra taken?

Levitra is available in oral tablets containing 2.5, 5, 10, or 20 mg of active drug. The recommended starting dose is 10 mg, taken one hour before sexual activity. Thereafter, the dose may be increased to a maximum of 20 mg or decreased to 5 mg based on effectiveness and tolerability. The maximum recommended dosing frequency is once per day.

How does Levitra work?

During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates an enzyme called guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The increased cGMP triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection.

How quickly does Levitra work?

Levitra is rapidly absorbed with peak circulating levels achieved between 30 minutes and 2 hours after taking.

What are the possible side-effects of Levitra?

The most common side effects (occurring in >2% of treated patients) likely attributable to the use of Levitra are as follows:

  • Headache
  • Flushing
  • Rhinitis ("runny nose")
  • Dyspepsia (indigestion)
  • Accidental injury
  • Sinusitis (sinus inflammation)
  • Flu-like syndrome
  • Dizziness
  • Increased creatine kinase (an enzyme released from muscle tissue)
  • Nausea

What other medications interact with Levitra?

The following drugs are known or likely to produce drug interactions with Levitra:

  • Amyl nitrate and butyl nitrate
  • Prescription nitrates
  • Alpha-blockers
  • Anti-arrythmics like quinidine, procainamide, amiodarone and sotalol
  • Ritonavir, indinavir, saquinavir or atazanavir
  • Ketoconazole or itraconazole
  • Erythromycin or clarithromycin
*The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.