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Xenical

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What is Xenical?

Xenical (Orlistat) is used with a reduced-calorie diet to help significantly overweight persons lose weight. It also helps to prevent regaining weight previously lost. Xenical (Orlistat) works by blocking some of the fat normally digested by the intestine.

How do you use Xenical?

Take this drug by mouth, generally three times daily during (or up to one hour after) each main meal that contains fat. Your daily intake of fat, protein and carbohydrate should be evenly spread over three main meals. If a meal is occasionally missed or contains no fat, skip that dose of the medication. Because Xenical can interfere with absorption of fat-soluble vitamins (e.g., A,D,E,K), a daily multivitamin supplement containing these nutrients is recommended. Take the multivitamin at least 2 hours before or 2 hours after this drug (e.g., at bedtime). The effects of this drug may begin as soon as 1-2 days after treatment begins; noticeable weight loss will take longer.

What are the side effects associated with Xenical?

Fatty/oily stool, oily spotting, intestinal gas with discharge, bowel movement urgency, poor bowel control, or headaches may occur. If these effects persist or worsen, notify your doctor promptly. Intestinal side effects (e.g., oily stool) may increase in intensity if you exceed your daily dietary fat allowance. If you notice other effects not listed above, contact your doctor or pharmacist.

What other drugs can have negative interactions with Xenical?

Tell your doctor of all prescription and nonprescription medication you use, especially of: cyclosporine, "blood thinners" (e.g., warfarin), drugs for diabetes (e.g., insulin), other drugs used for weight loss. Cyclosporine should be taken at least 2 hours before or after Xenical (Orlistat) to assure maximum absorption of the cyclosporine into your bloodstream. Do not start or stop any medicine without doctor or pharmacist approval.

What should you know about Xenical?

Tell your doctor your medical history, including: allergies, digestive disorders (malabsorption or cholestasis), low thyroid function (hypothyroidism), other metabolism problems (e.g., oxalate kidney stones, hyperoxaluria). This drug should not be used if you have anorexia nervosa or bulimia-type eating disorders. Tell your doctor if you are pregnant before using this medication. The manufacturer does not recommend use of this drug during pregnancy. It is not known whether Xenical is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Do not share Xenical with others. Follow your doctor-approved nutritional, reduced-calorie diet containing about 30 percent calories from fat. Also, exercise is recommended; however, first consult your doctor or pharmacist.

*The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.